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KMID : 1123920030170051288
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 5 p.1288 ~ p.1292
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Cytotoxic Activity of Methanol Fractions and Solvent Extracts from Houttuynia cordata (IX) on Various Cancer Cells
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Lee Jeong-Ho
Baek Seung-Hwa
Lim Jin-A
Chun Hyun-Ja
Lee Ki-Nam
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Abstract
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This study was carried out to evaluate cytotoxic effects of Houttuynia cordata T/sub HUNB/ extracts on A549 (lung cancer), MDA-MB231 (breast cancer), SNU-C4 (colon cancer) and B16 (mouse melanoma) cell lines. We have determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT) assay. The 150 ㎍/㎖ concentration of methanol extract (63.81 %) of Houttuynia cordata T/sub HUNB/ was shown significantly antitoxic activity on A549 cell lines. The order of cytotoxicity fractions of methanol from Houttuynia cordata T/sub HUNB/ extracts against cancer cell lines in vitro is as follows : hexane fraction layer > chloroform fraction layer > ethyl acetate fraction layer > buthanol fraction layer > water fraction layer. These results suggest that the hexane fraction of methanol extract from Houttuynia cordata T/sub HUNB/ extract may be a valuable choice for the development of antitumor agents.
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KEYWORD
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Houttuynia cordata T/sub HUNB/, MTT assay, Cytotoxic effect
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